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KMID : 1134819960250060976
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Journal of the Korean Society of Food Science and Nutrition
1996 Volume.25 No. 6 p.976 ~ p.980
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Effect of the Combination of Ethanol with Toluene Treatment for a Short Time Period on the Toluene Metabolizing Enzyme Activity
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Yoon Chong-Guk
Jeon Jai-Hyun
Shin Joong-Kyu
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Abstract
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To elucidate the effect of acute ethanol pretreatment on some toluene metabolizing enzyme activities, rats were divided into 4groups: control, alcohol-treated, toluene-treated, rat’s and toluene-treated rats pretreated with ethanol. The alcohol or toluene-treated rats showed the significantly increased activities of hepatic aniline hydroxylase(AH) and aminopyrine demethylase(AD) compared to the control group. And the toluene-treated rats pretreated with ethanol showed somewhat decreased tendency of these enzyme activities compared to only toluene-treated rats. Liver benzylalcohol or aldehyde dehydrogenase activities were higher in alcohol or toluene-treated rats than those of the control group. The toluene-treated rats showed the decreased tendency of benzylalcohol dehydrogenase activities by the pretreatment of alcohol. Furthermore, toluene treated-rats showed the markedly decreased activity of benzaldehyde dehydrogenase by the ethanol pretreat-ment. On the other hand, hepatic xanthine oxidase activity in toluene-treated animals pretreated with ethanol was significantly higher than those of the toluene alone-treated rats. These results indicate that the combination of ethanol with toluene treatment for a short period of time possibly results in decreased activity of some toluene metabolizing enzymes in rats.
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KEYWORD
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toluene, ethanol, hepatic aniline hydroxylase, aminopyrine demethylase, benzylalcohol and aldehyde dehydrogenase
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